Better Vaccines
for Better Future
About TaiU
Dr. Min-Shi Lee has more than 30 years experiences in vaccine research and development including 6 years R&D in USA vaccine company, and several national vaccine development projects of enterovirus, influenza H5N1, H7N9 and seasonal influenza. To strengthen and grow Taiwan’s vaccine business, Dr. Min-Shi Lee’s group has established a start-up company for developing bivalent enterovirus vaccines and seasonal influenza virus-like particle (VLP) vaccines and also expend to more diseases area through this innovative technology platforms.
- PhD, Oxford University, UK
- MPH, National Taiwan University
- Investigator, NHRI, Taiwan (2005~)
- Scientist, Aviron/Medimmune (1999~2005)
- NIPM (former CDC), Taiwan (1993~1998)
- >30 years for vaccine research including measles, JEV, influenza (FluMist licensed in USA) , PIV3, and EV71 (licensed in Taiwan)
- Built Asia-Pacific Network for Enterovirus Surveillance (APNES)
Technology
Main Product
Innovative platform of enterovirus and influenza VLP vaccines
- Promising option to combat viruses mutation
- Provide a broad-spectrum prevention with better immunogenicity
- Enable faster scaling-up
Influenza vaccines Development
1st generation
Egg-based inactivated Vaccines
• Takes 20 weeks to produce
• Need live virus
• Mutations in HA
2nd generation
Cell-based inactivated Vaccines
• Takes 16 weeks to produce
• Need live virus
• Few mutations in HA
3rd generation
Recombinant Protein Vaccines
• Reduce to only 12 weeks production
• No mutations in HA
• No live viruses
• Ready for emerging viruses (novel influenza, etc.)
Market Share %
Egg-based inactivated Vaccines
Cell-based inactivated Vaccines
Recombinant Protein Vaccines
Current Recombinant Protein flu Vaccine Development
| Company | Platforms | HA antigen doses |
|---|---|---|
|
NHRI Spin-off |
VLP using Insect cells (Sf21 and Hi5) |
15-30 µg/strain |
|
Sanofi*
|
rHA using Insect cell (Sf9)
|
45 µg/strain
|
|
Medicago (bankruptcy in 2023) |
VLP using plant (tobacco plant) |
30 µg/strain |
|
Novavax |
rHA using
Insect cell (Sf9) |
60 µg/strain with adjuvant
|
Contact Us
- Email: cchiu@nhri.edu.tw
- Phone: +886 932 796 340
- Address: 35, Keyan Road, Zhunan Town, Miaoli County 350, Taiwan, ROC
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